[CAS NO. 473719-41-4] AMG 487
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PRODUCTS SPECIFICATIONS [473719-41-4]
Store
Catalog
SLK-S8682
Brand
Selleck
CAS
473719-41-4
DESCRIPTION [473719-41-4]
Overview
| MDL | MFCD11111772 |
|---|---|
| Molecular Weight | 603.59 |
| Molecular Formula | C32H28F3N5O4 |
| SMILES | O=C(N([C@@H](C1=NC2=NC=CC=C2C(N1C3=CC=C(OCC)C=C3)=O)C)CC4=CC=CN=C4)CC5=CC=C(OC(F)(F)F)C=C5 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6568 mL | 8.2838 mL | 16.5675 mL |
| 5 mM | 0.3314 mL | 1.6568 mL | 3.3135 mL |
| 10 mM | 0.1657 mL | 0.8284 mL | 1.6568 mL |
| 50 mM | 0.0331 mL | 0.1657 mL | 0.3314 mL |
Description
AMG 487 is an orally active and selective antagonist that inhibits the binding of IP-10 (CXCL10) and ITAC (CXCL11) to CXCR3 with IC50 of 8.0 nM and 8.2 nM, respectively.
In vitro
AMG487 is the targeted blocker of chemokine receptor CXCR3 and improves inflammatory symptoms by blocking the inflammatory cycle. AMG487 significantly affects DC maturity in vitro and function leading to impaired T cell activation, inducing DCs to have characteristics similar to tolerogenic DCs. AMG487 may directly play an immunomodulatory role during DC development and functional shaping.
References
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