[CAS NO. 919486-40-1] AS1517499
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PRODUCTS SPECIFICATIONS [919486-40-1]
Store
Catalog
SLK-S8685
Brand
Selleck
CAS
919486-40-1
DESCRIPTION [919486-40-1]
Overview
| MDL | MFCD24038757 |
|---|---|
| Molecular Weight | 397.86 |
| Molecular Formula | C20H20ClN5O2 |
| SMILES | O=C(C1=CN=C(NCCC2=CC=C(O)C(Cl)=C2)N=C1NCC3=CC=CC=C3)N |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5134 mL | 12.5672 mL | 25.1345 mL |
| 5 mM | 0.5027 mL | 2.5134 mL | 5.0269 mL |
| 10 mM | 0.2513 mL | 1.2567 mL | 2.5134 mL |
| 50 mM | 0.0503 mL | 0.2513 mL | 0.5027 mL |
Description
AS1517499 is a novel and potent inhibitor with an IC50 value of 21 nM.
Targets
| STAT6 [1] (Cell-free assay) |
| 21 nM |
In vitro
AS1517499 inhibit IL-4-induced Th2 differentiation of mouse spleen T cells, but has no influence on Th1 differentiation induced by IL-12. AS1517499 is able to prevent the IL-4-activated STAT6-mediated increase of the clonogenic potential of primary PCa cells. At a dose of 300 nM, AS1517499 decreases the clonogenic potential of primary basal PCa cells.
In vivo
In vivo treatment with AS1517499 ameliorates the antigen-induced bronchial smooth muscle (BSM) hyperresponsiveness by inhibiting the RhoA up-regulation in BSMs and, at least in part, by reducing the IL-13 production in the airways in mice. AS1517499 reduces preventive effects of apoptotic cell instillation on bleomycin-induced lung fibrosis by suppressing PPARγ.
References
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