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Catalog:
SLK-S8696
Brand:
Selleck
CAS:
144707-18-6
Overview
MDL
MFCD27995567
Molecular Weight
270.24
Molecular Formula
C15H10O5
SMILES
O=C1C=C(C2=CC=C(O)C(O)=C2O)OC3=C1C=CC=C3
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
3.7004 mL
18.5021 mL
37.0041 mL
5 mM
0.7401 mL
3.7004 mL
7.4008 mL
10 mM
0.3700 mL
1.8502 mL
3.7004 mL
50 mM
0.0740 mL
0.3700 mL
0.7401 mL
Description
2-D08 (2',3',4'-trihydroxy flavone) is a cell permeable, mechanistically unique inhibitor of .
Targets
In vitro
2-D08, a inhibitor of protein SUMOylation, enhances the all-trans retinoic acid (ATRA)-induced expression of key genes involved in differentiation, proliferation, and apoptosis in non-APL AML cells. 2-D08 inhibits sumoylation by preventing transfer of SUMO from the UBC9-SUMO thioester to the substrate.
