[CAS NO. 1644342-14-2] ML792
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PRODUCTS SPECIFICATIONS [1644342-14-2]
Catalog
SLK-S8697
Brand
Selleck
CAS
1644342-14-2
DESCRIPTION [1644342-14-2]
Overview
| MDL | MFCD32174257 |
|---|---|
| Molecular Weight | 551.41 |
| Molecular Formula | C21H23BrN6O5S |
| SMILES | O=S(OC[C@@H]1[C@@H](O)C[C@H](NC2=NC=NC=C2C(C3=NN(CC4=CC=CC(Br)=C4)C=C3)=O)C1)(N)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8135 mL | 9.0677 mL | 18.1353 mL |
| 5 mM | 0.3627 mL | 1.8135 mL | 3.6271 mL |
| 10 mM | 0.1814 mL | 0.9068 mL | 1.8135 mL |
| 50 mM | 0.0363 mL | 0.1814 mL | 0.3627 mL |
Description
ML-792 is a potent and selective inhibitor of . ML-792 inhibits SAE/SUMO1 and SAE/SUMO2 in ATP–inorganic pyrophosphate (PPi) exchange assays with IC50 of 3 nM and 11 nM, respectively.
In vitro
ML-792 is a mechanism-based SUMO-activating enzyme (SAE) inhibitor with nanomolar potency in cellular assays. ML-792 selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation. Induction of the MYC oncogene increases the ML-792-mediated viability effect in cancer cells, thus indicating a potential application of SAE inhibitors in treating MYC-amplified tumors.
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