[CAS NO. 2130033-55-3] PHY34

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PRODUCTS SPECIFICATIONS [2130033-55-3]

Catalog

SLK-S8744

Brand

Selleck

CAS

2130033-55-3

DESCRIPTION [2130033-55-3]

Overview

MDL	-
Molecular Weight	582.55
Molecular Formula	C30H30O12
SMILES	COC1=CC2=C(C=C1OC)C(=C3C(=O)OCC3=C2OC4OC(CO)C5OC(C)(C)OC5C4O)C6=CC=C7OCOC7=C6

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.7166 mL	8.5830 mL	17.1659 mL
5 mM	0.3433 mL	1.7166 mL	3.4332 mL
10 mM	0.1717 mL	0.8583 mL	1.7166 mL
50 mM	0.0343 mL	0.1717 mL	0.3433 mL

Description

PHY34 is a late-stage inhibitor with nanomolar potency and significant antitumor efficacy as a single agent against HGSOC in vivo.

Targets

autophagy ^[1]

In vitro

PHY34 is a cytotoxic compound in both HGSOC cell lines with an IC50 of 4 nM. It has nanomolar IC50s in both MDA-MB-435 and MDAMB-231 cell lines and is more cytotoxic against MDA-MB-231 (PHY34 IC50 in MDA-MB-435 = 23 nM, PHY34 IC50 in MDA-MB-231 = 5.2 nM). PHY34 treatment (100 nM) results in significant increases in early and late apoptotic cells in OVCAR3.

References

[1] Young AN, et al. Mol Cancer Ther. 2018, 17(10):2123-2135.