[CAS NO. 1622902-68-4] Abrocitinib (PF-04965842)

Name: Abrocitinib (PF-04965842)
Brand: Arctom Scientific
SKU: SLK-S8765

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PRODUCTS SPECIFICATIONS [1622902-68-4]

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Catalog

SLK-S8765

Brand

Selleck

CAS

1622902-68-4

DESCRIPTION [1622902-68-4]

Overview

MDL	MFCD30187577
Molecular Weight	323.41
Molecular Formula	C14H21N5O2S
SMILES	N(C)(C1=C2C(NC=C2)=NC=N1)[C@H]3C[C@@H](NS(CCC)(=O)=O)C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.0921 mL	15.4603 mL	30.9205 mL
5 mM	0.6184 mL	3.0921 mL	6.1841 mL
10 mM	0.3092 mL	1.5460 mL	3.0921 mL
50 mM	0.0618 mL	0.3092 mL	0.6184 mL

Description

Abrocitinib (PF-04965842) is a potent inhibitor with IC50s of 29 nM, 803 nM, > 10 000 nM and 1250 nM for JAK1, JAK2, JAK3 and tyrosine kinase (TYK) 2, respectively.

Targets

JAK1 ^[1] (Cell-free assay)	JAK2 ^[1] (Cell-free assay)	TYK2 ^[1] (Cell-free assay)
29 nM	803 nM	1.253 μM

In vitro

Abrocitinib (PF-04965842) is a potent JAK inhibitor with IC50 of 29 and 803 nM for JAK1 and JAK2, respectively.

References

[1] Vazquez ML, et al. J Med Chem. 2018, 61(3):1130-1152.

Synonyms

1-Propanesulfonamide, N-[cis-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-

N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide

N-[cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide

PF 04965842

Abrocitinib