[CAS NO. 2095616-82-1] CH7057288
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PRODUCTS SPECIFICATIONS [2095616-82-1]
Store
Catalog
SLK-S8788
Brand
Selleck
CAS
2095616-82-1
DESCRIPTION [2095616-82-1]
Overview
| MDL | MFCD31715415 |
|---|---|
| Molecular Weight | 569.67 |
| Molecular Formula | C32H31N3O5S |
| SMILES | O=C1C2=CC=C(NS(=O)(C)=O)C=C2C(C)(C)C3=C1C4=CC=C(C#CC5=CC(C(NC(C)(C)C)=O)=CC(C)=N5)C=C4O3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
CH7057288 is a potent and selective inhibitor with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB, and TRKC respectively.
Targets
In vitro
CH7057288 shows selective inhibitory activity against TRKA, TRKB, and TRKC in cell-free kinase assays and suppresses proliferation of TRK fusion-positive cell lines, but not that of TRK-negative cell lines. CH7057288 suppresses mitogen-activated protein kinase (MAPK) and E2F pathways as downstream signaling of TRK fusion.
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