[CAS NO. 1622849-43-7] GSK3145095

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PRODUCTS SPECIFICATIONS [1622849-43-7]

Catalog

SLK-S8845

Brand

Selleck

CAS

1622849-43-7

DESCRIPTION [1622849-43-7]

Overview

MDL	-
Molecular Weight	397.38
Molecular Formula	C20H17F2N5O2
SMILES	-

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.5165 mL	12.5824 mL	25.1648 mL
5 mM	0.5033 mL	2.5165 mL	5.0330 mL
10 mM	0.2516 mL	1.2582 mL	2.5165 mL
50 mM	0.0503 mL	0.2516 mL	0.5033 mL

Description

GSK3145095 is a potent and orally active inhibitor with IC50 of 6.3 nM with potential antineoplastic and immunomodulatory activities.

Targets

RIP1 kinase ^[1]
(Cell-free assay)

6.3 nM

In vitro

GSK3145095 potently binds to RIP1 with exquisite kinase specificity and has excellent activity in blocking RIP1 kinasedependent cellular responses. Highlighting its potential as a novel cancer therapy, the inhibitor is also able to promote a tumor suppressive T cell phenotype in pancreatic adenocarcinoma organ cultures.

References

[1] Philip A Harris, et al. ACS Med Chem Lett. 2019 May 9;10(6):857-862.