[CAS NO. 1832578-30-9] MLT-748
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PRODUCTS SPECIFICATIONS [1832578-30-9]
Catalog
SLK-S8898
Brand
Selleck
CAS
1832578-30-9
DESCRIPTION [1832578-30-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 492.32 |
| Molecular Formula | C19H19Cl2N9O3 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
MLT-748 is a potent, selective and allosteric inhibitor of with IC50 of 5 nM, binding at the interface between the caspase and immunoglobulin (Ig3) domains by displacing Trp580 and locking the catalytic site in an inactive state.
Targets
| MALT1 [1] (Cell-free assay) |
| 5 nM |
In vitro
MLT-748 binds MALT1 in the allosteric Trp580 pocket. MLT-748 binds and stabilizes mutant MALT1-W580S. Cleavage of MALT1 substrates is blocked by MLT-748 in B and T cells. MLT-748 rescues MALT1 function in patient MALT1 lymphocytes.
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