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Catalog:
SLK-S8943
Brand:
Selleck
CAS:
327031-55-0
Overview
MDL
MFCD01305422
Molecular Weight
317.35
Molecular Formula
C17H15N7
SMILES
C/C(C1=NC=CC=C1)=N\NC2=NN=C3C(NC4=C3C=CC=C4C)=N2
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
3.1511 mL
15.7555 mL
31.5110 mL
5 mM
0.6302 mL
3.1511 mL
6.3022 mL
10 mM
0.3151 mL
1.5755 mL
3.1511 mL
50 mM
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Description
VLX600 is a novel iron-chelating inhibitor of , potentiates the effect of radiation in tumor spheroids in a synergistic manner. VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation. VLX600 induces and with antitumor activity.
VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation. Mitochondrial inhibition with VLX600 has a direct antitumor effect in vitro while appearing to promote glycolysis through increased AKT signaling and glucose transporter expression. When combined with imatinib, VLX600 prevents imatinib-induced cell cycle escape and reduces p27 expression, leading to increased apoptosis when compared to imatinib alone.
