[CAS NO. 2369751-30-2] G150
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PRODUCTS SPECIFICATIONS [2369751-30-2]
Catalog
SLK-S8944
Brand
Selleck
CAS
2369751-30-2
DESCRIPTION [2369751-30-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 391.25 |
| Molecular Formula | C18H16Cl2N4O2 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5559 mL | 12.7796 mL | 25.5591 mL |
| 5 mM | 0.5112 mL | 2.5559 mL | 5.1118 mL |
| 10 mM | 0.2556 mL | 1.2780 mL | 2.5559 mL |
| 50 mM | 0.0511 mL | 0.2556 mL | 0.5112 mL |
Description
G150 is a potent and highly selective inhibitor with IC50 of 10.2 nM.
Targets
| h-cGAS [1] (Cell-free assay) |
| 10.2 nM |
In vitro
The most potent h-cGAS-specific derivative with 2-amino pyridine (G150) shows inhibitory activity in THP1 cells and primary human macrophages while a complete absence of off-target effect on a diverse range of sensors. G150 also shows no substantial cellular toxicity.
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