[CAS NO. 2416417-65-5] MYF-01-37

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [2416417-65-5]

Catalog

SLK-S8950

Brand

Selleck

CAS

2416417-65-5

DESCRIPTION [2416417-65-5]

Overview

MDL	-
Molecular Weight	298.3
Molecular Formula	C15H17F3N2O
SMILES	-

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.3523 mL	16.7616 mL	33.5233 mL
5 mM	0.6705 mL	3.3523 mL	6.7047 mL
10 mM	0.3352 mL	1.6762 mL	3.3523 mL
50 mM	0.0670 mL	0.3352 mL	0.6705 mL

Description

MYF-01-37 is a novel covalent inhibitor of targeting Cys380 when incubated with the TEAD2 protein.

Targets

TEAD ^[1]

In vitro

MYF-01-37 is developed as a covalent binder to TEAD, targeting Cys380 when incubated with the TEAD2 protein (C359 in TEAD1). Pretreating cells with MYF-01-37 leads to loss of direct TEAD pull-down by biotin-MYF-01-037 from whole-cell lysate, confirming MYF-01-037 binding to TEAD in cells.

References

[1] Kari J Kurppa, et al. Cancer Cell. 2020 Jan 13;37(1):104-122.e12.