[CAS NO. 2378626-29-8] TED-347
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PRODUCTS SPECIFICATIONS [2378626-29-8]
Catalog
SLK-S8951
Brand
Selleck
CAS
2378626-29-8
DESCRIPTION [2378626-29-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 313.70 |
| Molecular Formula | C15H11ClF3NO |
| SMILES | FC(C1=CC(NC2=CC=CC=C2C(CCl)=O)=CC=C1)(F)F |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1878 mL | 15.9388 mL | 31.8776 mL |
| 5 mM | 0.6376 mL | 3.1878 mL | 6.3755 mL |
| 10 mM | 0.3188 mL | 1.5939 mL | 3.1878 mL |
| 50 mM | 0.0638 mL | 0.3188 mL | 0.6376 mL |
Description
TED-347 is a potent, irreversible, covalent and allosteric inhibitor of . TED-347 inhibits TEAD4⋅Yap1 protein-protein interaction with an apparent EC50 of 5.9 μM.
Targets
| TEAD4⋅Yap1 [1] (Cell-free assay) |
| 5.9 μM(EC50) |
In vitro
TED-347 is found to inhibit the protein-protein interaction in a time-dependent manner. TED-347 is shown to functionally disrupt the TEAD·Yap1 interaction in cells and to reduce the viability of patient-derived glioblastoma cell lines.
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