[CAS NO. 2139287-33-3] THAL-SNS-032
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PRODUCTS SPECIFICATIONS [2139287-33-3]
Catalog
SLK-S8979
Brand
Selleck
CAS
2139287-33-3
DESCRIPTION [2139287-33-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 869.02 |
| Molecular Formula | C40H52N8O10S2 |
| SMILES | CC(C)(C)C1=CN=C(CSC2=CN=C(NC(C3CCN(CC(NCCOCCOCCOCCNC4=CC=CC5=C4C(N(C6C(NC(CC6)=O)=O)C5=O)=O)=O)CC3)=O)S2)O1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.1507 mL | 5.7536 mL | 11.5072 mL |
| 5 mM | 0.2301 mL | 1.1507 mL | 2.3014 mL |
| 10 mM | 0.1151 mL | 0.5754 mL | 1.1507 mL |
| 50 mM | 0.0230 mL | 0.1151 mL | 0.2301 mL |
Description
THAL-SNS-032 is a selective degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the .
In vitro
THAL-SNS-032 is a selective CDK9 degrader consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative which binds the E3 ubiquitin ligase Cereblon (CRBN). THAL-SNS-032 induces rapid degradation of CDK9 without affecting the levels of other SNS-032 targets. The transcriptional changes elicited by THAL-SNS-032 are more like those caused by NVP-2 than those induced by SNS-032. Strikingly, compound washout does not significantly reduce levels of THAL-SNS-032-induced apoptosis, suggesting that CDK9 degradation had prolonged cytotoxic effects compared to CDK9 inhibition.
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