Please click "REQUEST A QUOTE" button if there is no stock, or
you need other sizes or custom synthesis.
Catalog:
SLK-S9031
Brand:
Selleck
CAS:
173932-75-7
Overview
MDL
-
Molecular Weight
630.77
Molecular Formula
C38H46O8
SMILES
-
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
1.5854 mL
7.9268 mL
15.8536 mL
5 mM
0.3171 mL
1.5854 mL
3.1707 mL
10 mM
0.1585 mL
0.7927 mL
1.5854 mL
50 mM
0.0317 mL
0.1585 mL
0.3171 mL
Description
Gambogenic Acid, identified from Gamboge, is an inhibitor of the signaling pathway in erlotinib-resistant non-small-cell lung cancer (NSCLC) and exhibits anti-tumor effects. Gambogenic acid acts is also an effective inhibitor of that specifically and covalently binds to Cys668 within the EZH2-SET domain, and triggers EZH2 ubiquitination.
Gambogenic acid as a novel agent that specifically and covalently bound to Cys668 within the EZH2‐SET domain, triggers EZH2 degradation through COOH terminus of Hsp70‐interacting protein (CHIP)‐mediated ubiquitination. Gambogenic acid significantly suppresses H3K27Me3 and effectively reactivated polycomb repressor complex 2 (PRC2)‐silenced tumor suppressor genes. Gambogenic acid significantly suppresses tumor growth in an EZH2‐dependent manner.
