[CAS NO. 497871-47-3] Lurbinectedin (PM01183)

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PRODUCTS SPECIFICATIONS [497871-47-3]

Catalog

SLK-S9603

Brand

Selleck

CAS

497871-47-3

DESCRIPTION [497871-47-3]

Overview

MDL	MFCD22665743
Molecular Weight	784.87
Molecular Formula	C41H44N4O10S
SMILES	O[C@@H]1N2[C@@]([C@]3(C=4C([C@@]2(COC(=O)[C@@]5(CS3)C6=C(C=7C(N6)=CC=C(OC)C7)CCN5)[H])=C8C(=C(C)C4OC(C)=O)OCO8)[H])([C@]9(C=%10C(C[C@@]1(N9C)[H])=CC(C)=C(OC)C%10O)[H])[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Lurbinectedin (PM01183, PM-1183, LY-01017, Tryptamicidin, Zepsyre, ZEPZELCA), a covalent binder with potent in vitro and in vivo anti-tumour activity. Lurbinectedin inhibits RMG1 and RMG2 cell growth with IC50 of 1.25 nM and 1.16 nM, respectively.

Targets

DNA minor groove ^[1]	RMG2 cell growth ^[1] (Cell-based assay)	RMG1 cell growth ^[1] (Cell-based assay)
	1.16 nM	1.25 nM

In vitro

Lurbinectedin exhibits significant antitumor activity toward chemosensitive and chemoresistant CCC cells in vitro. Lurbinectedin plus SN-38 combination has strong synergistic effects on both the cisplatin-resistant and paclitaxel-resistant CCC cell lines.

References

[1] Ryoko Takahashi, et al. PLoS One. 2016 Mar 17;11(3):e0151050.
[2] J F M Leal, et al. Br J Pharmacol. 2010 Nov;161(5):1099-110.

Synonyms

Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′-[1H]pyrido[3,4-b]indol]-19-one, 5-(acetyloxy)-2′,3′,4′,6,6a,7,9′,13,14,16-decahydro-8,14-dihydroxy-6′,9-dimethoxy-4,10,23-trimethyl-, (1′R,6R,6aR,7R,13S,14S,16R)-

PM 01183

Lurbinectedin

Tryptamicidin

Zepsyre

PM 1183

(1′R,6R,6aR,7R,13S,14S,16R)-8,14-dihydroxy-6′,9-dimethoxy-4,10,23-trimethyl-19-oxo-2′,3′,4′,6,7,9′,12,13,14,16-decahydro-6aH-spiro[7,13-azano-6,16-(epithiopropanooxymethano)[1,3]dioxolo[7,8]isoquinolino[3,2-b][3]benzazocine-20,1′-pyrido[3,4-b]indol]-5-yl acetate

Zepzelca