[CAS NO. 568-80-9] Galloflavin

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PRODUCTS SPECIFICATIONS [568-80-9]

Catalog

SLK-S9606

Brand

Selleck

CAS

568-80-9

DESCRIPTION [568-80-9]

Overview

MDL	MFCD26941292
Molecular Weight	278.17
Molecular Formula	C12H6O8
SMILES	O=C(O1)C(O)=CC(OC2=O)=C1C3=C2C=C(O)C(O)=C3O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Galloflavin (NSC 107022) is a novel inhibitor of with Ki values of 5.46 μM and 15.06 μM for LDH-A and LDH-B, respectively.

Targets

LDH-A ^[1] (Cell-free assay)	LDH-B ^[1] (Cell-free assay)
5.46 µM(Ki)	15.06 µM(Ki)

In vitro

Galloflavin inhibits both human LDH isoforms by preferentially binding the free enzyme, without competing with the substrate or cofactor. The calculated Ki values for pyruvate are 5.46 mm (LDH-A) and 15.06 mm (LDH-B). In cultured tumor cells, galloflavin blocks aerobic glycolysis at micromolar concentrations, not interferes with cell respiration, and induces cell death by triggering apoptosis.

References

[1] Marcella Manerba, et al.ChemMedChem. 2012 Feb 6;7(2):311-7.
[2] Guo L, et al. Front Pharmacol. 2021 Dec 10;12:752118.