Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
1.8035 mL
9.0175 mL
18.0349 mL
5 mM
0.3607 mL
1.8035 mL
3.6070 mL
10 mM
0.1803 mL
0.9017 mL
1.8035 mL
50 mM
0.0361 mL
0.1803 mL
0.3607 mL
Description
Amcenestrant (SAR439859, compound 43d) is an orally available and nonsteroidal selective degrader (SERD) with potential antineoplastic activity. SAR439859 is a potent antagonist with EC50 of 0.2 nM for ERα degradation.
SAR439859 is a novel, orally bioavailable SERD with potent antagonist and degradation activities against both wild-type and mutant Y537S ER. Driven by its fluoropropyl pyrrolidinyl side chain, SAR439859 has demonstrated broader and superior ER antagonist and degrader activities across a large panel of ER+ cells, including inhibition of ER signaling and tumor cell growth.
