[CAS NO. 127779-20-8] Saquinavir (Ro 31-8959)

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Catalog:	SLK-S9625
Brand:	Selleck
CAS:	127779-20-8

Overview

MDL	MFCD00866925
Molecular Weight	670.84
Molecular Formula	C38H50N6O5
SMILES	C([C@H]([C@H](CC1=CC=CC=C1)NC([C@@H](NC(=O)C2=NC3=C(C=C2)C=CC=C3)CC(N)=O)=O)O)N4[C@H](C(NC(C)(C)C)=O)C[C@]5([C@@](C4)(CCCC5)[H])[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.4907 mL	7.4533 mL	14.9067 mL
5 mM	0.2981 mL	1.4907 mL	2.9813 mL
10 mM	0.1491 mL	0.7453 mL	1.4907 mL
50 mM	0.0298 mL	0.1491 mL	0.2981 mL

Description

Saquinavir (Ro 31-8959,SAQ) is a potent and selective inhibitor of with a mean IC50 of 2.7 nM in JM cells.

Targets

HIV proteinase ^[1]
(in JM cells)

2.7 nM

In vitro

Saquinavir (Ro 31-8959) is an effective selective HIV protease inhibitor with an average IC50 of 2.7 nM in JM cells, which inhibits the spread of HIV infection and the production of cytopathic effects.^[1]

References

[1] J C Craig, et al. Antiviral Res . 1991 Dec;16(4):295-305.

Synonyms

Butanediamide, N¹-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-, (2S)-

Butanediamide, N¹-[3-[3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-, [3S-[2[1R*(R*),2S*],3α,4aβ,8aβ]]-

(2S)-N¹-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-Dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]butanediamide

Ro 31-8959

(S)-N-[(αS)-α-[(1R)-2-[(3S,4aS,8aS)-3-(tert-Butylcarbamoyl)octahydro-2(1H)-isoquinolyl]-1-hydroxyethyl]phenethyl]-2-quinaldamidosuccinamide

Saquinavir

Sch 52852

Ro 31-8959/000

Fortovase

Sequinavir

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