[CAS NO. 1353900-92-1]  Pibrentasvir (ABT-530)

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PRODUCTS SPECIFICATIONS [1353900-92-1]

Catelog
SLK-S9641
Brand
Selleck
CAS
1353900-92-1

DESCRIPTION [1353900-92-1]

Overview

MDLMFCD30747902
Molecular Weight1113.18
Molecular FormulaC57H65F5N10O8
SMILESFC1=C([C@@H]2N([C@H](CC2)C3=C(F)C=C4C(NC([C@@H]5CCCN5C([C@@H](NC(OC)=O)[C@H](OC)C)=O)=N4)=C3)C6=CC(F)=C(C(F)=C6)N7CCC(CC7)C8=CC=C(C=C8)F)C=C9C(N=C(N9)[C@@H]%10CCCN%10C([C@@H](NC(OC)=O)[C@H](OC)C)=O)=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM0.8983 mL4.4916 mL8.9833 mL
5 mM0.1797 mL0.8983 mL1.7967 mL
10 mM0.0898 mL0.4492 mL0.8983 mL
50 mM0.0180 mL0.0898 mL0.1797 mL

Description

Pibrentasvir (ABT-530) is a novel and pan-genotypic inhibitor with EC50 ranging from 1.4 pM to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6.

Targets


In vitro

Pibrentasvir is a next-generation HCV NS5A inhibitor with potent and pan-genotypic activity, and it maintains activity against common amino acid substitutions of HCV genotypes 1 to 6 that are known to confer resistance to currently approved NS5A inhibitors.