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Catalog:
SLK-S9665
Brand:
Selleck
CAS:
664334-36-5
Overview
MDL
-
Molecular Weight
2159.52
Molecular Formula
C97H144FN33O19S2
SMILES
-
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
0.4631 mL
2.3153 mL
4.6307 mL
5 mM
0.0926 mL
0.4631 mL
0.9261 mL
10 mM
0.0463 mL
0.2315 mL
0.4631 mL
50 mM
-
-
-
Description
Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) is an antagonist of with IC50 of ～1 nM. BL-8040 induces the of AML blasts by down-regulating , , and via altered miR-15a/16-1 expression.
Treatment with BL-8040 induces the robust mobilization of AML blasts from the BM. In addition, AML cells exposed to BL-8040 undergoes differentiation. BL-8040 induces the apoptosis of AML cells in vitro. This apoptosis is mediated by the up-regulation of miR-15a/miR-16-1, resulting in down-regulation of the target genes BCL-2, MCL-1 and cyclin-D1. Overexpression of miR-15a/miR-16-1 directly induces leukemic cell death. BL-8040-induced apoptosis is also mediated by the inhibition of survival signals via the AKT/ERK pathways.
