[CAS NO. 79338-84-4] Tapinarof

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Catalog:	SLK-S9700
Brand:	Selleck
CAS:	79338-84-4

Overview

MDL	-
Molecular Weight	254.32
Molecular Formula	C17H18O2
SMILES	C(=C/C1=CC=CC=C1)\C2=CC(O)=C(C(C)C)C(O)=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

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Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.9321 mL	19.6603 mL	39.3205 mL
5 mM	0.7864 mL	3.9321 mL	7.8641 mL
10 mM	0.3932 mL	1.9660 mL	3.9321 mL
50 mM	0.0786 mL	0.3932 mL	0.7864 mL

Description

Tapinarof (GSK2894512, Benvitimod, WBI 1001, DHPS, DMVT 505) is a natural agonist of and induces nuclear translocation of AhR in immortalized keratinocytes (HaCaT) with EC50 of 0.16 nM. Tapinarof induces cellular in CD4+ T cells in a dosedependent manner with IC50 of 5.2 μM.

Targets

AhR ^[1] (in immortalized keratinocytes)	apoptosis ^[1] (in CD4+ T cells)
0.16 nM(EC50)	5.2 μM

In vitro

Tapinarof binds and activates AhR in multiple cell types, including cells of the target tissue –human skin. In addition, tapinarof moderates proinflammatory cytokine expression in stimulated peripheral blood CD4+ T cells and ex vivo human skin, and impacts barrier gene expression in primary human keratinocytes; both of these processes are likely to be downstream of AhR activation based on current evidence.

References

[1] Susan H Smith, et al. J Invest Dermatol. 2017 Oct;137(10):2110-2119.

Synonyms

1,3-Benzenediol, 2-(1-methylethyl)-5-[(1E)-2-phenylethenyl]-

1,3-Benzenediol, 2-(1-methylethyl)-5-(2-phenylethenyl)-, (E)-

2-(1-Methylethyl)-5-[(1E)-2-phenylethenyl]-1,3-benzenediol

3,5-Dihydroxy-4-isopropyl-trans-stilbene

WBI 1001

Tapinarof

(E)-2-Isopropyl-5-styrylbenzene-1,3-diol

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