[CAS NO. 195514-63-7] Rimiducid (AP1903)

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PRODUCTS SPECIFICATIONS [195514-63-7]

Catalog

SLK-S9726

Brand

Selleck

CAS

195514-63-7

DESCRIPTION [195514-63-7]

Overview

MDL	MFCD25976784
Molecular Weight	1411.63
Molecular Formula	C78H98N4O20
SMILES	O=C(N1[C@@H](CCCC1)C(O[C@@H](C2=CC(OCC(NCCNC(COC3=CC([C@@H](CCC4=CC(OC)=C(C=C4)OC)OC([C@H]5N(CCCC5)C([C@H](C6=CC(OC)=C(C(OC)=C6)OC)CC)=O)=O)=CC=C3)=O)=O)=CC=C2)CCC7=CC(OC)=C(C=C7)OC)=O)[C@H](C8=CC(OC)=C(C(OC)=C8)OC)CC

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	0.7084 mL	3.5420 mL	7.0840 mL
5 mM	0.1417 mL	0.7084 mL	1.4168 mL
10 mM	0.0708 mL	0.3542 mL	0.7084 mL
50 mM	0.0142 mL	0.0708 mL	0.1417 mL

Description

Rimiducid (AP1903) is a chemical protein dimerizer and binds tightly to the target while binding minimally to the abundant natural FKBP. Rimiducid elicites potent and dose-dependent apoptosis of cells in culture expressing dimerizer-dependent Fas constructs, with an EC50 of ≈0.1 nM.

Targets

FKBP fusion protein ^[1]

In vitro

Rimiducid (AP1903) induces effective and dose-dependent apoptosis in the culture expressing dimer-dependent Fas constructors, indicating that Rimiducid causes the activation of Fas signaling without interference from endogenous FKBP.^[2]

References

[1] J D Iuliucci, et al. J Clin Pharmacol. 2001 Aug;41(8):870-9.
[2] T Clackson, et al. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10437-42.