[CAS NO. 870153-29-0] PF-00835231
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PRODUCTS SPECIFICATIONS [870153-29-0]
Catalog
SLK-S9731
Brand
Selleck
CAS
870153-29-0
DESCRIPTION [870153-29-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 472.53 |
| Molecular Formula | C24H32N4O6 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1163 mL | 10.5813 mL | 21.1627 mL |
| 5 mM | 0.4233 mL | 2.1163 mL | 4.2325 mL |
| 10 mM | 0.2116 mL | 1.0581 mL | 2.1163 mL |
| 50 mM | 0.0423 mL | 0.2116 mL | 0.4233 mL |
Description
PF-00835231 is a inhibitor that may targets SARS-CoV-2 protease 3CL as a potential new treatment for COVID-19.
Targets
| 3CLpro [1] |
In vitro
A time-of-drug-addition approach delineates the timing of early SARS-CoV-2 life cycle steps in A549 cells and validates PF-00835231's early time of action. In a model of the human polarized airway epithelium, PF-00835231 potently inhibits SARS-CoV-2 at low micromolar concentrations. PF-00835231 exhibits the potential as an effective SARS-CoV-2 antiviral.
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