Please click "REQUEST A QUOTE" button if there is no stock, or
you need other sizes or custom synthesis.
Catalog:
SLK-S9743
Brand:
Selleck
CAS:
1370554-01-0
Overview
MDL
-
Molecular Weight
392.62
Molecular Formula
C17H8Cl3N3O2
SMILES
-
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
2.5470 mL
12.7350 mL
25.4699 mL
5 mM
0.5094 mL
2.5470 mL
5.0940 mL
10 mM
0.2547 mL
1.2735 mL
2.5470 mL
50 mM
0.0509 mL
0.2547 mL
0.5094 mL
Description
Ciliobrevin D (compound 5) is a cell-permeable, reversible and specific antagonist of AAA+ (ATPases associated with diverse cellular activities) ATPase motor . Ciliobrevin D perturbs primary cilia formation and blocks signaling.
Ciliobrevin D inactivate dynein in Sertoli cells. The inactivation of dynein by ciliobrevin D also perturbs gross disruption of F-actin across the Sertoli cells in vitro. Ciliobrevin D perturbs protein trafficking within the primary cilium, leading to their malformation and Hedgehog signaling blockade. Ciliobrevin D also prevents spindle pole focusing, kinetochore-microtubule attachment, melanosome aggregation, and peroxisome motility in cultured cells.
