[CAS NO. 2227368-54-7] JH-X-119-01
Please click "REQUEST A QUOTE" button if you need other sizes or
custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis,
please:
PRODUCTS SPECIFICATIONS [2227368-54-7]
Catalog
SLK-S9780
Brand
Selleck
CAS
2227368-54-7
DESCRIPTION [2227368-54-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 452.46 |
| Molecular Formula | C25H20N6O3 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
JH-X-119-01 is a highly potent and selective covalent inhibitor of with IC50 of 9 nM.
Targets
| IRAK1 [1] (Cell-free assay) |
| 9 nM |
In vitro
JH-X-119-01 is a highly efficient and selective covalent inhibitor of interleukin 1 (IL-1) receptor-associated kinase (IRAK) 1 and irreversibly labels IRAK1 at C302, showing moderate cell killing effects with EC50s ranging from 0.59 to 9.72 μM in a panel of WM cells, DLBCL cells, and lymphoma cells.[1]
Powered by Arctom Copyright © 2026 Arctom.
All rights reserved.