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Catalog:
SLK-S9786
Brand:
Selleck
CAS:
2414572-47-5
Overview
MDL
-
Molecular Weight
561.03
Molecular Formula
C29H29ClN6O4
SMILES
-
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
1.7824 mL
8.9122 mL
17.8244 mL
5 mM
0.3565 mL
1.7824 mL
3.5649 mL
10 mM
0.1782 mL
0.8912 mL
1.7824 mL
50 mM
-
-
-
Description
BDTX-189 is a potent and selective inhibitor of allosteric and oncogenic mutations with Kd of 0.2 nM, 0.76 nM, 13 nM and 1.2 nM for EGFR, HER2, and , reapectively. BDTX-189 exhibits anticancer activity.
BDTX-189 is a potent, selective, irreversible active site inhibitor of the ERBB allosteric mutant oncogene family. BDTX-189 achieves a superior selectivity profile in cell-based assays.
