[CAS NO. 2414572-47-5] BDTX-189

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PRODUCTS SPECIFICATIONS [2414572-47-5]

Catalog

SLK-S9786

Brand

Selleck

CAS

2414572-47-5

DESCRIPTION [2414572-47-5]

Overview

MDL	-
Molecular Weight	561.03
Molecular Formula	C29H29ClN6O4
SMILES	-

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.7824 mL	8.9122 mL	17.8244 mL
5 mM	0.3565 mL	1.7824 mL	3.5649 mL
10 mM	0.1782 mL	0.8912 mL	1.7824 mL
50 mM	-	-	-

Description

BDTX-189 is a potent and selective inhibitor of allosteric and oncogenic mutations with Kd of 0.2 nM, 0.76 nM, 13 nM and 1.2 nM for EGFR, HER2, and , reapectively. BDTX-189 exhibits anticancer activity.

Targets

EGFR ^[1] (Cell-free assay)	HER2 ^[1] (Cell-free assay)	RIPK2 ^[1] (Cell-free assay)	BLK ^[1] (Cell-free assay)
0.2 nM(Kd)	0.76 nM(Kd)	1.2 nM(Kd)	13 nM(Kd)

In vitro

BDTX-189 is a potent, selective, irreversible active site inhibitor of the ERBB allosteric mutant oncogene family. BDTX-189 achieves a superior selectivity profile in cell-based assays.

References

[1] Elizabeth Buck, PhD. 32nd EORTC-NCI-AACR Virtual Symposium; October 24–25, 2020