[CAS NO. 2369979-67-7] JHU37152

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PRODUCTS SPECIFICATIONS [2369979-67-7]

Catalog

SLK-S9789

Brand

Selleck

CAS

2369979-67-7

DESCRIPTION [2369979-67-7]

Overview

MDL	-
Molecular Weight	358.84
Molecular Formula	C19H20ClFN4
SMILES	-

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.7868 mL	13.9338 mL	27.8676 mL
5 mM	0.5574 mL	2.7868 mL	5.5735 mL
10 mM	0.2787 mL	1.3934 mL	2.7868 mL
50 mM	0.0557 mL	0.2787 mL	0.5574 mL

Description

JHU37152 is a agonist with Ki of 1.8 nM and 8.7 nM for and in vitro, respectively. And EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.

Targets

hM4Di ^[1] (Cell-free assay)	hM3Dq ^[1] (Cell-free assay)	hM3Dq ^[1] (Cell-free assay)	hM4Di ^[1] (Cell-free assay)
0.5 nM(EC50)	1.8 nM(Ki)	5 nM(EC50)	8.7 nM(Ki)

In vitro

JHU37152 is a potent DREADD agonist with high potency and efficacy in fluorescent and BRET-based assays in HEK-293 cells, whereas no responses are observed in untransfected HEK-293 cells.

References

[1] Jordi Bonaventura, et al. Nat Commun. 2019 Oct 11;10(1):4627.