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Catalog:
SLK-S9789
Brand:
Selleck
CAS:
2369979-67-7
Overview
MDL
-
Molecular Weight
358.84
Molecular Formula
C19H20ClFN4
SMILES
-
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
2.7868 mL
13.9338 mL
27.8676 mL
5 mM
0.5574 mL
2.7868 mL
5.5735 mL
10 mM
0.2787 mL
1.3934 mL
2.7868 mL
50 mM
0.0557 mL
0.2787 mL
0.5574 mL
Description
JHU37152 is a agonist with Ki of 1.8 nM and 8.7 nM for and in vitro, respectively. And EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.
JHU37152 is a potent DREADD agonist with high potency and efficacy in fluorescent and BRET-based assays in HEK-293 cells, whereas no responses are observed in untransfected HEK-293 cells.