[CAS NO. 2369979-68-8] JHU37160

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PRODUCTS SPECIFICATIONS [2369979-68-8]

Catalog

SLK-S9790

Brand

Selleck

CAS

2369979-68-8

DESCRIPTION [2369979-68-8]

Overview

MDL	-
Molecular Weight	358.84
Molecular Formula	C19H20ClFN4
SMILES	-

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.7868 mL	13.9338 mL	27.8676 mL
5 mM	0.5574 mL	2.7868 mL	5.5735 mL
10 mM	0.2787 mL	1.3934 mL	2.7868 mL
50 mM	0.0557 mL	0.2787 mL	0.5574 mL

Description

JHU37160 is a agonist with Ki of 1.9 nM and 3.6 nM for and in vitro, respectively. And EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.

Targets

hM4Di ^[1] (Cell-free assay)	hM3Dq ^[1] (Cell-free assay)	hM4Di ^[1] (Cell-free assay)	hM3Dq ^[1] (Cell-free assay)
0.2 nM(EC50)	1.9 nM(Ki)	3.6 nM(Ki)	18.5 nM(EC50)

In vitro

JHU37160 is a potent DREADD agonist with high potency and efficacy in fluorescent and BRET-based assays in HEK-293 cells, whereas no responses are observed in untransfected HEK-293 cells.

References

[1] Jordi Bonaventura, et al. Nat Commun. 2019 Oct 11;10(1):4627.