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Catalog:
SLK-S9817
Brand:
Selleck
CAS:
2376255-48-8
Overview
MDL
-
Molecular Weight
569.05
Molecular Formula
C26H37ClN4O8
SMILES
-
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
1.7573 mL
8.7866 mL
17.5731 mL
5 mM
0.3515 mL
1.7573 mL
3.5146 mL
10 mM
0.1757 mL
0.8787 mL
1.7573 mL
50 mM
0.0351 mL
0.1757 mL
0.3515 mL
Description
Ac-FLTD-CMK is a specific inhibitor for inflammatory . Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage by caspases-1, -4, -5, and -11 in vitro. Ac-FLTD-CMK is effective against caspases-1, caspases-4 and caspases-5 with IC50 of 46.7 nM, 1.49 μM and 329 nM, respectively.
A GSDMD-derived inhibitor, N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone (Ac-FLTD-CMK), inhibits GSDMD cleavage in vitro and suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes.
