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Catalog:
SLK-S9839
Brand:
Selleck
CAS:
1467047-25-1
Overview
MDL
-
Molecular Weight
352.47
Molecular Formula
C22H28N2O2
SMILES
-
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
2.8371 mL
14.1856 mL
28.3712 mL
5 mM
0.5674 mL
2.8371 mL
5.6742 mL
10 mM
0.2837 mL
1.4186 mL
2.8371 mL
50 mM
0.0567 mL
0.2837 mL
0.5674 mL
Description
SRS11-92 (AA9), a Ferrostatin-1 (Fer-1) analogue, is a potent inhibitor of . SRS11-92 inhibits ferroptotic cell death induced by Erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM.
Targets
HT-1080 ferroptotic cell death [1] (Cell-based assay)
6 nM(EC50)
In vitro
SRS11-92 is efficacious in protecting human and mouse cellular models of FRDA treated with ferric ammonium citrate (FAC) and an inhibitor of glutathione synthesis (BSO). SRS11-92 decreases the cell death associated with frataxin knockdown in healthy human fibroblasts.
