[CAS NO. 1154-25-2] 5-(N-Ethyl-N-isopropyl)-Amiloride (EIPA)

Name: 5-(N-Ethyl-N-isopropyl)-Amiloride (EIPA)
Brand: Arctom Scientific
SKU: SLK-S9849

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PRODUCTS SPECIFICATIONS [1154-25-2]

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Catalog

SLK-S9849

Brand

Selleck

CAS

1154-25-2

DESCRIPTION [1154-25-2]

Overview

MDL	MFCD00151710
Molecular Weight	299.76
Molecular Formula	C11H18ClN7O
SMILES	N(C(C)C)(CC)C=1C(Cl)=NC(C(NC(=N)N)=O)=C(N)N1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

5-(N-Ethyl-N-isopropyl)-Amiloride (EIPA) acts as an inhibitor of and (IC50=0.033μg/mL). EIPA blocks the activity of , which are plasma membrane proteins implicated in all forms of macropinocytosis.

Targets

NHE ^[1]
(in the Sodium-hydrogen exchanger activity assay)

0.033 μg/mL

In vitro

5-(N-Ethyl-N-isopropyl)-Amiloride (EIPA) rapidly and reversibly block Ca-activated TRPP3 channel activation, with ICs of 10.5 μM.

References

[1] Verma V, et al. J Basic Clin Physiol Pharmacol. 2014 Feb;25(1):99-108.
[2] Dai XQ, et al. Mol Pharmacol. 2007 Dec;72(6):1576-85.
[3] Chen YX, et al. Circulation. 2004 Dec 14;110(24):3721-6.

Synonyms

2-Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-

Pyrazinecarboxamide, N-amidino-3-amino-6-chloro-5-(ethylisopropylamino)-

Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-

3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide

5-(N-Ethyl-N-isopropyl)amiloride

L 593754

EIPA

MH 12-43

Ethylisopropylamiloride

3-Amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide