[CAS NO. 2519823-34-6] BSJ-4-116
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PRODUCTS SPECIFICATIONS [2519823-34-6]
Catalog
SLK-S9859
Brand
Selleck
CAS
2519823-34-6
DESCRIPTION [2519823-34-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 837.38 |
| Molecular Formula | C40H49ClN8O8S |
| SMILES | O=C(NCCCCCCCN1C[C@H](NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(C(C)C)=O)=N2)CCC1)COC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
BSJ-4-116 is a specific degrader of . BSJ-4-116 exhibits potent antiproliferative effects.
Targets
| CDK12 [1] |
In vitro
BSJ-4-116 selectively degrads CDK12 as assessed through quantitative proteomics. BSJ-4-116 downregulates the expression of DDR genes and exhibits antiproliferative activity in cancer cells. BSJ-4-116 also substantially suppresses the phosphorylation of Pol II Ser2 and Thr4.
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