[CAS NO. 2499663-01-1] STM2457
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PRODUCTS SPECIFICATIONS [2499663-01-1]
Catalog
SLK-S9870
Brand
Selleck
CAS
2499663-01-1
DESCRIPTION [2499663-01-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 444.53 |
| Molecular Formula | C25H28N6O2 |
| SMILES | O=C(C(N=C1N2C=CC=C1)=CC2=O)NCC3=CN4C=C(CNCC5CCCCC5)C=CC4=N3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
STM2457 is a highly potent and selective first-in-class catalytic inhibitor of RNA Methyltransferase with an IC50 of 16.9 nM. STM2457 is highly specific for METTL3 and showed no inhibition of other RNA methyltransferases.
Targets
| METTL3 [1] (Cell-free assay) |
| 16.9 nM |
In vitro
STM2457 has a highly efficient and selective catalytic inhibition on RNA methyltransferase METTL3, causing gene-expression defects consistent with an effect on the mRNA translational efficiency of mA substrates.
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