[CAS NO. 2229974-83-6] MS140
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PRODUCTS SPECIFICATIONS [2229974-83-6]
Catalog
SLK-S9880
Brand
Selleck
CAS
2229974-83-6
DESCRIPTION [2229974-83-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 760.80 |
| Molecular Formula | C39H40N10O7 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.3144 mL | 6.5720 mL | 13.1441 mL |
| 5 mM | 0.2629 mL | 1.3144 mL | 2.6288 mL |
| 10 mM | 0.1314 mL | 0.6572 mL | 1.3144 mL |
| 50 mM | - | - | - |
Description
MS140 is a specific and highly potent inhibitor and also a CDK4/6 degrader (PROTAC).
In vitro
MS140 potently and selectively both inhibits and degrades CDK4/6 kinases in CDK4/6i-S tumor cells by targeting them to the CRL4–CRBN–E3 ubiquitin complex.
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