Biotin-PEG4-Alkyne (CAS NO.: 1458576-00-5) is a PEG linker featuring a biotin group and a terminal alkyne. The biotin group is ideal for affinity-based applications, such as pull-down assays, and for binding to streptavidin proteins with high specificity. The terminal alkyne enables copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), forming stable triazoles with azide-containing molecules.
This biotin-labeled, PEG-based linker is widely used in the synthesis of PROTACs, as well as in bioconjugation and chemical biology research. Its hydrophilic PEG spacer enhances solubility, making it a valuable tool for creating functionalized molecules in drug discovery and biomolecular applications.
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