[CAS NO. 78782-99-7] Calcitriol-d6
PRODUCTS SPECIFICATIONS [78782-99-7]
DESCRIPTION [78782-99-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 422.67 |
| Molecular Formula | C27H38D6O3 |
| SMILES | C=C1/C(C[C@H](C[C@@H]1O)O)=C\C=C2CCC[C@]3(C)[C@@H]([C@@H](CCCC(C([2H])([2H])[2H])(C([2H])([2H])[2H])O)C)CC[C@@]/23[H] |
Summary
Calcitriol-d6 is the deuterium labeled Calcitriol. Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor ( VDR ) [1] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years |
* The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
DMSO : 50 mg/mL ( 118.30 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3659 mL | 11.8296 mL | 23.6591 mL |
| 5 mM | 0.4732 mL | 2.3659 mL | 4.7318 mL |
| 10 mM | 0.2366 mL | 1.1830 mL | 2.3659 mL |
References
- [1] Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. Beer and Myrthue (2004)
- [2] Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373.
- [3] Nijenhuis et al (2006) The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist. FASEB J. 20 1589.
- [4] Krishnan AV, Swami S, Feldman D.Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: Importance of mammary CYP27B1 for treatment and prevention.J Steroid Biochem Mol Biol. 2012 Aug 23.
- [5] Alkharfy KM, Al-Daghri NM, Yakout SM, Ahmed M.Calcitriol Attenuates Weight-Related Systemic Inflammation and Ultrastructural Changes of the Liver in a Rodent Model.Basic Clin Pharmacol Toxicol. 2012 Aug 21.