[CAS NO. 83657-22-1] Uniconazole

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PRODUCTS SPECIFICATIONS [83657-22-1]

Catalog

HY-B0873

Brand

MCE

CAS

83657-22-1

DESCRIPTION [83657-22-1]

Overview

MDL	-
Molecular Weight	291.78
Molecular Formula	C15H18ClN3O
SMILES	OC(C(C)(C)C)/C(N1N=CN=C1)=C\C2=CC=C(Cl)C=C2

For research use only. We do not sell to patients.

Summary

Uniconazole, a plant growth retardant, is a potent inhibitor of abscisic acid (ABA) catabolism with an IC ₅₀ of 68 nM against ABA 8’-hydroxylase. Uniconazole is a potent competitive inhibitor of CYP707A3 activity with a K _i of 8 nM. Uniconazole evidently inhibits gibberellin biosynthesis, and brassinosteroid biosynthesis is also inhibited to some extent ^[1] .

IC50 & Target

IC ₅₀ : 68 nM (ABA 8’-hydroxylase) ^[1]
K _i : 8 nM (CYP707A3 activity) ^[1]

In Vivo

Uniconazole (0-50 μM) effectively blocks ABA 8’-hydroxylase activity and enhances drought tolerance in vivo ^[1] .
Uniconazole increases the activities of antioxidant enzymes, promotes accumulation of proline and soluble sugars, and reduces accumulation of malondialdehyde ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Arabidopsis ^[1]
Dosage:	0.5, 1, 5, 25, 50 μM
Administration:
Result:	Inhibited PA (phaseic acid) production and enhanced drought tolerance.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 342.72 mM ; Need ultrasonic)

H ₂ O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4272 mL	17.1362 mL	34.2724 mL
5 mM	0.6854 mL	3.4272 mL	6.8545 mL
10 mM	0.3427 mL	1.7136 mL	3.4272 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (8.57 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (8.57 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (8.57 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

1H-1,2,4-Triazole-1-ethanol, β-[(4-chlorophenyl)methylene]-α-(1,1-dimethylethyl)-, (βE)-

1H-1,2,4-Triazole-1-ethanol, β-[(4-chlorophenyl)methylene]-α-(1,1-dimethylethyl)-, (E)-(±)-

(βE)-β-[(4-Chlorophenyl)methylene]-α-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol

Uniconazole

XE 1019

Sumagic

Prunit

M 13144

Sumiseven

XE 1019D

S 3307D

S 327D

S 07

S 3307

Majic S 3307D

Majic

1H-1,2,4-Triazole-1-ethanol, β-[(4-chlorophenyl)methylene]-α-(1,1-dimethylethyl)-, (E)-

Pentefenzol

(E)-1-(4-Chlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)-1-penten-3-ol

(βE)-β-[(4-Chlorophenyl)methylene]-α-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol