5K Scaffold Library

Format & Volume

10 μL/well Solution

30 μL/well Solution

50 μL/well Solution

100 μL/well Solution

Compounds

5,000

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ATTRIBUTES

Store

Catalog

HY-L902

Brand

MCE

OVERVIEW

MCE 5K Scaffold Library consists of 5,000 lead-like compounds. Each compound represents one unique scaffold. All compounds are compatible with Lipinski’s rule (Rule of 5) with multiple characteristics such as calculated good solubility (-3.2 < logP < 5), oral bioavailability (RotB <= 10), drug transportability (PSA < 120). Compounds contained within the library have been screened to remove any inappropriate chemical structures, avoiding “false hits”. The sufficient diverse of compound structure makes this library a powerful tool for drug screening.

Description & Advantages

Name: 5K Scaffold Library
Brand: Arctom Scientific
SKU: HY-L902

• Maximum structural diversity.

• Each compound represents one unique scaffold. 5,000 unique scaffods (Bemis-Murcko) totally.

• Compatible with Lipinski’s rule (Rule of 5), with multiple characteristics such as calculated good solubility (-3.2 < logP < 5), oral bioavailability (RotB <= 10), drug transportability (PSA < 120), MW between 300 to 500, number of Hydrogen Bond Donor (HBD) ≤ 5, number of Hydrogen Bond Acceptor (HBA) ≤ 10.

• Passed all associated MedChem filters, particularly pan assay interference compound (PAINS) motifs, to remove any inappropriate chemical structures and avoid false hits.

• All 5,000 compounds are available off the shelf. Pre-plates of 10 mM DMSO solutions, convenient to use.

• NMR and HPLC validated to ensure high purity and quality.

Product Details