[CAS NO. 26833-85-2] Harringtonine

Name: Harringtonine
Brand: Arctom Scientific
SKU: HY-N0862

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PRODUCTS SPECIFICATIONS [26833-85-2]

Distributor

Catalog

HY-N0862

Brand

MCE

CAS

26833-85-2

DESCRIPTION [26833-85-2]

Overview

MDL	-
Molecular Weight	531.59
Molecular Formula	C28H37NO9
SMILES	O=C([C@@](CC(OC)=O)(O)CCC(C)(O)C)O[C@H]1[C@](C2=CC(OCO3)=C3C=C2CCN4CCC5)([H])[C@]45C=C1OC

For research use only. We do not sell to patients.

6 Publications Citing Use of MCE

Summary

Harringtonine is a natural Cephalotaxus alkaloid that inhibits protein synthesis . Harringtonine has anti- chikungunya virus (CHIKV) activities with an EC ₅₀ of 0.24 μM.

In Vitro

Harringtonine inhibits the elongation phase of translation by preventing substrate binding to the acceptor site on the 60-S ribosome subunit and therefore block aminoacyl-tRNA binding and peptide bond formation ^[1] . Harringtonine displays potent inhibition of Chikungunya virus infection with an EC ₅₀ of 0.24 μM. Harringtonine could inhibit other alphaviruses ^[2] . Harringtonine inhibits the growth of human myeloid leukemia cells in vitro at low concentrations. The mechanism of the antitumor action of harringtonine is considered to be an effect on protein synthesis and is characterized by breakdown of polysomes to monosomes ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 188.11 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8811 mL	9.4057 mL	18.8115 mL
5 mM	0.3762 mL	1.8811 mL	3.7623 mL
10 mM	0.1881 mL	0.9406 mL	1.8811 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.70 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (4.70 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.70 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Cephalotaxine, 3-[4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate]

Harringtonine

Cephalotaxine, 4-methyl 2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate (ester), [3(R)]-

Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate (ester)

4H-Cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepine, cephalotaxine deriv.

Harringtonin

2′R-Harringtonine

NSC 124147