[CAS NO. 125317-39-7] Vinorelbine ditartrate (KW-2307)

Name: Vinorelbine ditartrate (KW-2307)
Brand: Arctom Scientific
SKU: SLK-S4269

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PRODUCTS SPECIFICATIONS [125317-39-7]

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Catalog

SLK-S4269

Brand

Selleck

CAS

125317-39-7

DESCRIPTION [125317-39-7]

Overview

MDL	-
Molecular Weight	1079.11
Molecular Formula	C45H54N4O8.2C4H6O6
SMILES	[C@@H]([C@H](C(O)=O)O)(C(O)=O)O.C(C)[C@@]12[C@]3([C@@]4([C@]([C@](C(OC)=O)(O)[C@@H]1OC(C)=O)(N(C)C=5C4=CC(=C(OC)C5)[C@]6(C(OC)=O)C7=C(C=8C(N7)=CC=CC8)C[N@@]9C[C@](C6)(C=C(CC)C9)[H])[H])CCN3CC=C2)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	0.9267 mL	4.6334 mL	9.2669 mL
5 mM	0.1853 mL	0.9267 mL	1.8534 mL
10 mM	0.0927 mL	0.4633 mL	0.9267 mL
50 mM	0.0185 mL	0.0927 mL	0.1853 mL

Description

Vinorelbine Tartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate) is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with . Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic , and inflammation.

Features

A semi-synthetic vinca alkaloid as an anti-mitotic chemotherapy drug.

Targets

Tubulin ^[1]
(Cell-free assay)

In vitro

Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. Vinorelbine shows potent antiproliferative activity against a series of tumor cells, including human melanoma, non-small-cell lung cancer, breast cancer, etc.

References

[1] Fellous A, et al. Semin Oncol. 1989, 16(2 Suppl 4), 9-14.
[2] Photiou A, et al. J Cancer Res Clin Oncol. 1992, 118(4), 249-254.
[3] Zhou YT, et al. Asian Pac J Cancer Prev. 2013, 14(8), 4635-4639.
[4] Xu YC, et al. Breast J. 2013, 19(2), 180-188.
[5] Hill BT, et al. Eur J Cancer. 1999, 35(3), 512-520.
[6] Sachdev P, et al. Cancers (Basel). 2022 Sep 19;14(18):4532.

Synonyms

Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)

C′-Norvincaleukoblastine, 3′,4′-didehydro-4′-deoxy-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (1:2) (salt)

Vinorelbine ditartrate

KW 2307

Navelbine ditartrate

Vinorelbine tartrate

Navelbine

Nor-5′-anhydrovinblastine ditartrate

Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)

3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine tartrate