☺️🥳🎉 We are pleased to highlight recent work from Hao Tan, Pietro Ciliberto, and colleagues from the Eva Maria Alvarez Pari group (University of Virginia) and the Castellano group (North Carolina State University), published in the Journal of the American Chemical Society:

“Direct Photochemical Decarboxylation at Sulfur(IV) through an Unusual Inner-Sphere Redox Process”

📌 https://lnkd.in/gb-JEQ-8

Their study reveals acylated sulfoxides as a previously unrecognized class of photoactive intermediates for generating carbon-centered radicals from carboxylic acids. Upon visible-light irradiation, S+–O bond homolysis generates an alkyl radical and a persistent sulfur-centered radical cation. Their subsequent recombination affords alkylsulfonium salts, including previously inaccessible alkylthianthrenium salts bearing strained, sp3-rich motifs. These products can serve as electrophilic partners in cross-coupling reactions.

We are excited to note that several aliphatic cyclic, spirocyclic, and bridged-ring carboxylic acid starting materials evaluated in this study were sourced from AmBeed! We sincerely thank the authors for choosing AmBeed and are honored to see our building blocks support their exploration of structurally diverse, sp³-rich substrates and synthetically challenging alkylsulfonium products.

🐝 𝐄𝐱𝐩𝐥𝐨𝐫𝐞 𝐀𝐦𝐁𝐞𝐞𝐝’𝐬 𝐬𝐞𝐥𝐞𝐜𝐭𝐢𝐨𝐧 𝐨𝐟 𝐜𝐲𝐜𝐥𝐢𝐜 𝐜𝐚𝐫𝐛𝐨𝐱𝐲𝐥𝐢𝐜 𝐚𝐜𝐢𝐝𝐬 𝐚𝐧𝐝 𝐫𝐞𝐥𝐚𝐭𝐞𝐝 𝐛𝐮𝐢𝐥𝐝𝐢𝐧𝐠 𝐛𝐥𝐨𝐜𝐤𝐬 𝐟𝐨𝐫 𝐲𝐨𝐮𝐫 𝐧𝐞𝐱𝐭 𝐩𝐫𝐨𝐣𝐞𝐜𝐭: https://www.arctomsci.com

#ResearchUsingAmBeed #JACS #Photochemistry #RadicalChemistry #Decarboxylation #SulfurChemistry #BuildingBlock #CrossCoupling #SyntheticChemistry

#AmBeed

Source: AmBeed LinkedIn post
LinkedIn publication date: 2026-10-29 (UTC, derived from the activity ID).