What if one tiny fluorine atom could supercharge your PROTAC? ⚛️

Fluorinated CRBN ligands are a powerful medicinal chemistry trick for next-gen degraders:
• Tune binding affinity
• Boost metabolic stability & permeability
• Improve ternary complex formation
• Sharpen neosubstrate selectivity

Clinically validated:
🔹 ARV-766 (Phase II AR-PROTAC)
🔹 CFT-1946 (Phase I BRAF-PROTAC)
BMS-986449 shows the power: 96% IKZF2 degradation, with minimal off-target effects.

Our ready-to-use fluorinated CRBN building blocks cut synthetic bottlenecks. Your team can focus on linker & warhead optimization, not fragment synthesis.
What’s your biggest PROTAC synthetic challenge?

🌐 Learn more: www.arctomsci.com
✉️ Contact: [email protected]

#PROTAC #TargetedProteinDegradation #MedicinalChemistry #CRBN #DrugDiscovery #Biotech

Originally posted on LinkedIn: 2026-09-11 (UTC; date derived from the LinkedIn activity ID).

Source: ChemScene on LinkedIn