[CAS NO. 1000279-69-5] A-867744

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PRODUCTS SPECIFICATIONS [1000279-69-5]

Catalog

HY-12149

Brand

MCE

CAS

1000279-69-5

DESCRIPTION [1000279-69-5]

Overview

MDL	MFCD16495814
Molecular Weight	402.89
Molecular Formula	C20H19ClN2O3S
SMILES	O=S(C1=CC=C(C=C1)N2C(C)=C(C=C2C3=CC=C(C=C3)Cl)C(CC)=O)(N)=O

For research use only. We do not sell to patients.

Summary

A-867744 is a highly potent and selective type II positive allosteric modulator (PAM) of the alpha7 nicotinic acetylcholine receptors (nAChR) with an EC ₅₀ of 1.0 μM ^[1] .

IC50 & Target

EC50: 1.0 μM (alpha7 nAChR) ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 248.21 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4821 mL	12.4103 mL	24.8207 mL
5 mM	0.4964 mL	2.4821 mL	4.9641 mL
10 mM	0.2482 mL	1.2410 mL	2.4821 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.21 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.21 mM); Clear solution

* All of the co-solvents are available by MCE.