- Cart - 0 item(s)
- $0.00
Your shopping cart is empty!
- Chemistry
- Bioactive Molecules
- Anti-infection
- Apoptosis
- Autophagy
- Cell Cycle/DNA Damage
- Cytoskeleton
- Epigenetics
- GPCR/G Protein
- Immunology/Inflammation
- JAK/STAT Signaling
- MAPK/ERK Pathway
- Membrane Transporter/Ion Channel
- Metabolic Enzyme/Protease
- Neuronal Signaling
- NF-κB
- PI3K/Akt/mTOR
- PROTAC
- Protein Tyrosine Kinase/RTK
- Stem Cell/Wnt
- TGF-beta/Smad
- Vitamin D Related/Nuclear Receptor
- Others
- Methylation
- Cytoskeletal Signaling
- Natural Products
- Alkaloids
- Amino acid
- Anthraquinones
- Cerebrosides
- Chalcones
- Coumarins
- Diterpenoids
- Flavonoids
- Iridoids
- Lignans
- Lipids
- Miscellaneous
- Monoterpenoids
- Other terpenes
- Phenols
- Phenylpropanoids
- Quinones
- Saccharides
- Sesquiterpenoids
- Steroids
- Tetraterpenoids
- Thiophenes
- Triterpenoids
- Xanthones
- Polyphenols
- Stibene glucosides
- Oligose
- Anthocyanins
- Miscellaneous
- Chromones
- Terpenoids
- Indoles
- Procyanidins
- Aliphatics
- Botanical Cyclopeptides
- ADCs
- Antibodies
- Multiplex IHC
- Material Science
- Others
[CAS NO. 1002789-86-7] TZ9
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-18643 |
| Brand: | MCE |
| CAS: | 1002789-86-7 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 366.33 |
| Molecular Formula | C17H14N6O4 |
| SMILES | O=C(OCC1=NC(N)=NC(NC2=CC=CC=C2)=N1)C3=CC=C([N+]([O-])=O)C=C3 |
1 Publications Citing Use of MCE
Summary
In Vitro
TZ9 (Rad6B SMI #9) (0.5-100 µM; 72 h) inhibits MDA-MB-231 cell proliferation and migration
[1]
.
TZ9 (0.1-5 µM; 24-72 h) delays cell-cycle progression in MDA-MB-231 cells
[1]
.
TZ9 (5 µM; 8-48 h) induces apoptosis in MDA-MB-231 cells
[1]
.
TZ9 (0.5, 1, 2.5, 5 µM; 24 h) inhibits H2A ubiquitination and downregulates levels of PCNA and β-catenin protein in MDA-MB-231 cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay [1]
| Cell Line: | MDA-MB-231 cells |
| Concentration: | 0.5-100 µM |
| Incubation Time: | 72 h |
| Result: | Inhibited MDA-MB-231 cell proliferation with IC 50 ~6µM. |
Apoptosis Analysis [1]
| Cell Line: | MDA-MB-231 cells |
| Concentration: | 5 µM |
| Incubation Time: | 8-48 h |
| Result: | Induced cells apoptosis. |
Cell Cycle Analysis [1]
| Cell Line: | MDA-MB-231 cells |
| Concentration: | 0.1-5 µM |
| Incubation Time: | 24-72 h |
| Result: |
Increased the proportion of G2-M-arrested cells by 2-fold and was accompanied by a proportional decrease in S-phase cells when at 24 h.
Significantly increased the percentage of cells with cytoplasmic/nuclear cyclin B1 staining. |
Western Blot Analysis [1]
| Cell Line: | MDA-MB-231 cells |
| Concentration: | 0.5, 1, 2.5, 5 µM |
| Incubation Time: | 24 h |
| Result: | Inhibited H2A ubiquitination, decreased PCNA and β-catenin protein levels. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 40 mg/mL ( 109.19 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7298 mL | 13.6489 mL | 27.2978 mL |
| 5 mM | 0.5460 mL | 2.7298 mL | 5.4596 mL |
| 10 mM | 0.2730 mL | 1.3649 mL | 2.7298 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (5.68 mM); Clear solution
Arctom is a premier supply platform offering over 600K unique items of Building Blocks, Bioactive Molecules, Natural Products, ADC PEG Linkers, Antibodies, and other Research Chemicals for global pharmaceutical, biotech, university, and industrial customers. We accelerate your research by providing better and faster purchasing experience & services.