[CAS NO. 1010100-26-1] Lenalidomide-5-Br

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PRODUCTS SPECIFICATIONS [1010100-26-1]

Catalog

HY-W072954

Brand

MCE

CAS

1010100-26-1

DESCRIPTION [1010100-26-1]

Overview

MDL	MFCD32263142
Molecular Weight	323.14
Molecular Formula	C13H11BrN2O3
SMILES	O=C(C(N(CC1=C2C=CC(Br)=C1)C2=O)CC3)NC3=O

For research use only. We do not sell to patients.

Summary

Lenalidomide-5-Br is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-Br can be connected to the ligand for protein by a linker to form PROTAC ^[1] .

IC50 & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)

H ₂ O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)