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[CAS NO. 102115-79-7] Pseudoprotodioscin
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N0686 |
| Brand: | MCE |
| CAS: | 102115-79-7 |
Overview
| MDL | MFCD04039839 |
|---|---|
| Molecular Weight | 1031.18 |
| Molecular Formula | C51H82O21 |
| SMILES | C[C@@]1([C@](C(C)=C(CC[C@@H](C)CO[C@@H]([C@@H]([C@@H](O)[C@@H]2O)O)O[C@@H]2CO)O3)([H])[C@]3([H])C4)[C@]4([H])[C@@](CC=C5[C@@]6(CC[C@H](O[C@@](O[C@H](CO)[C@@H](O[C@@](O[C@@H](C)[C@H](O)[C@H]7O)([H])[C@@H]7O)[C@@H]8O)([H])[C@@H]8O[C@@](O[C@@H](C)[C@H](O)[C@H]9O)([H])[C@@H]9O)C5)C)([H])[C@]6([H])CC1 |
1 Publications Citing Use of MCE
Summary
Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides [1] .
In Vitro
In Hep G2 cells, Pseudoprotodioscin increases ABCA1 protein and mRNA levels, and promotes the effluxion of ApoA-1-mediated cholesterol. Pseudoprotodioscin inhibits SREBP1c and SREBP2 transcription by decreasing microRNA 33a/b levels. This procedure reciprocally lead to the increase of ABCA1 levels. In THP-1 macrophages, Pseudoprotodioscin shows the similar effect, which reduces HMGCR, FAS and ACC mRNA levels and promotes low density lipoprotein receptor by decreasing the PCSK9 levels [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
H 2 O : ≥ 100 mg/mL ( 96.98 mM )
DMSO : 100 mg/mL ( 96.98 mM ; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.9698 mL | 4.8488 mL | 9.6976 mL |
| 5 mM | 0.1940 mL | 0.9698 mL | 1.9395 mL |
| 10 mM | 0.0970 mL | 0.4849 mL | 0.9698 mL |
References
- [1] Gai Y, et al. Pseudoprotodioscin inhibits SREBPs and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides. Fitoterapia. 2019 Nov;139:104393.
- [2] Liang ZZ, et al. Oligofurostanosides from Asparagus cochinchinensis. Planta Med. 1988 Aug;54(4):344-6.
Synonyms
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