[CAS NO. 102396-24-7] Jasplakinolide
PRODUCTS SPECIFICATIONS [102396-24-7]
DESCRIPTION [102396-24-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 709.67 |
| Molecular Formula | C36H45BrN4O6 |
| SMILES | BrC1=C(C2=CC=CC=C2N1)C[C@@H](N(C([C@@H](NC([C@H](C/C(C)=C/[C@@H]3C)C)=O)C)=O)C)C(N[C@](C(C=C4)=CC=C4O)([H])CC(O[C@H](C3)C)=O)=O |
2 Publications Citing Use of MCE
Summary
Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a K d of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge , has both fungicidal and anti-cancer activity [1] [2] .
In Vitro
Jasplakinolide has an IC
50
of 35 nM for the antiproliferative effect of jasplakinolide on PC3 prostate carcinoma cells
[2]
.
Jasplakinolide (10 μM; for 2 hours) generates binucleated cells when applied during mitosis. Jasplakinolide induces the formation of F-actin-containing apical extensions in Toxoplasma gondii tachyzoites
[2]
.
Jasplakinolide (1 mM; for 60 min) induces the formation of actin-containing apical extensions in isolated Toxoplasma gondii tachyzoites fixed
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
marine sponge
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
References
- [1] Bubb MR, et al. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J Biol Chem. 1994 May 27;269(21):14869-71.
- [2] Holzinger A, et al. Jasplakinolide: an actin-specific reagent that promotes actin polymerization. Methods Mol Biol. 2009;586:71-87.