[CAS NO. 104757-53-1] Barnidipine hydrochloride
PRODUCTS SPECIFICATIONS [104757-53-1]
DESCRIPTION [104757-53-1]
Overview
| MDL | MFCD00915772 |
|---|---|
| Molecular Weight | 528.00 |
| Molecular Formula | C27H30ClN3O6 |
| SMILES | O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC([N+]([O-])=O)=CC=C2)O[C@@H]3CN(CC4=CC=CC=C4)CC3.[H]Cl |
Summary
Barnidipine hydrochloride (Mepirodipine hydrochloride) is an L-type calcium antagonist ( CaA ) with high affinity for [ 3 H] initrendipine binding sites ( K i =0.21 nmol/l), has selective action against CaA receptors [1] . Barnidipine hydrochloride (Mepirodipine hydrochloride) is an antihypertensive drug and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action [2] .
IC50 & Target
Ki: 0.21 nmol/l ([ 3 H] initrendipine) [1]
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 250 mg/mL ( 473.48 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.8939 mL | 9.4697 mL | 18.9394 mL |
| 5 mM | 0.3788 mL | 1.8939 mL | 3.7879 mL |
| 10 mM | 0.1894 mL | 0.9470 mL | 1.8939 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (3.94 mM); Clear solution
References
Synonyms