- Cart - 0 item(s)
- $0.00
Your shopping cart is empty!
- Chemistry
- Bioactive Molecules
- Anti-infection
- Apoptosis
- Autophagy
- Cell Cycle/DNA Damage
- Cytoskeleton
- Epigenetics
- GPCR/G Protein
- Immunology/Inflammation
- JAK/STAT Signaling
- MAPK/ERK Pathway
- Membrane Transporter/Ion Channel
- Metabolic Enzyme/Protease
- Neuronal Signaling
- NF-κB
- PI3K/Akt/mTOR
- PROTAC
- Protein Tyrosine Kinase/RTK
- Stem Cell/Wnt
- TGF-beta/Smad
- Vitamin D Related/Nuclear Receptor
- Others
- Methylation
- Cytoskeletal Signaling
- Natural Products
- Alkaloids
- Amino acid
- Anthraquinones
- Cerebrosides
- Chalcones
- Coumarins
- Diterpenoids
- Flavonoids
- Iridoids
- Lignans
- Lipids
- Miscellaneous
- Monoterpenoids
- Other terpenes
- Phenols
- Phenylpropanoids
- Quinones
- Saccharides
- Sesquiterpenoids
- Steroids
- Tetraterpenoids
- Thiophenes
- Triterpenoids
- Xanthones
- Polyphenols
- Stibene glucosides
- Oligose
- Anthocyanins
- Miscellaneous
- Chromones
- Terpenoids
- Indoles
- Procyanidins
- Aliphatics
- Botanical Cyclopeptides
- ADCs
- Antibodies
- Multiplex IHC
- Material Science
- Others
[CAS NO. 1062648-63-8] DMT1blocker2
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-126302 |
| Brand: | MCE |
| CAS: | 1062648-63-8 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 263.29 |
| Molecular Formula | C16H13N3O |
| SMILES | OC1=C2C3=C(C=CC=C3)CCC2=NN1C4=NC=CC=C4 |
Summary
DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 ( DMT1 ), with an IC 50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo [1] .
IC50 & Target
IC50: 0.83 μM (divalent metal transporter 1) [1]
In Vitro
In Vivo
DMT1 blocker 2 (50 mg/kg; p.o.) blocks iron uptake by enterocytes in an acute rat model of iron hyperabsorption [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Weanling (3-4 weeks) rats were placed on a low iron diet for four weeks [1] |
| Dosage: | 50 mg/kg |
| Administration: | Oral gavage followed 1 h later by an iron challenge |
| Result: | Attenuated the post-challenge serum iron increase. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 189.90 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.7981 mL | 18.9905 mL | 37.9809 mL |
| 5 mM | 0.7596 mL | 3.7981 mL | 7.5962 mL |
| 10 mM | 0.3798 mL | 1.8990 mL | 3.7981 mL |
Arctom is a premier supply platform offering over 600K unique items of Building Blocks, Bioactive Molecules, Natural Products, ADC PEG Linkers, Antibodies, and other Research Chemicals for global pharmaceutical, biotech, university, and industrial customers. We accelerate your research by providing better and faster purchasing experience & services.